Monitor renal and haematologic systems periodically during prolonged therapy or if high dose is used. Use may result in overgrowth of nonsusceptible organisms. Cross-sensitivity with cephalosporins may occur. History of significant allergies and/or asthma. Pregnancy and lactation.
Nausea, vomiting, epigastric distress, diarrhoea, black hairy tongue; skin eruptions (maculopapular to exfoliative dermatitis), urticaria and other serum-sickness like reactions, laryngeal oedema; fever, eosinophilia.
Potentially Fatal: Anaphylaxis.
Pregnancy Category
Name :
B
Description
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
Mode of Action
Inhibits the biosynthesis of cell wall mucopeptide; bactericidal against sensitive organisms when adequate concentrations are reached, and most effective during the stage of active multiplication; inadequate concentrations may produce only bacteriostatic effects.
Interaction
N/A
Pregnancy Category Note
N/A
Adult Dose
Oral
Adult:
Usually 250-500 mg 6 hourly
Prophylaxis of recurrent rheumatic fever
250 mg twice daily.
Streptococcal infections of the upper respiratory tract, including scarlet fever and erysipelas
125-250 mg 6-8 hrly for 10 days.
Pneumococcal infections of the respiratory tract, including otitis media
250-500 mg 6 hrly until patient is afebrile for at least 2 days.
Fusospirochetosis (Vincent's infection) of the oropharynx; Staphylococcal infections of the skin and soft tissue
250-500 mg 6-8 hrly.
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