Allergic disorders, coagulation defects; history of cardiac failure, left ventricular dysfunction, hypertension, or in patients with oedema due to other reasons; elderly, renal, cardiac or hepatic impairment. Withdraw treatment if GI lesions develop; caution when admin to dehydrated patients. Regular BP monitoring is advisable. May mask fever and other signs of infection. Pregnancy.
Indication
Rheumatoid arthritis, Osteoarthritis, Gout
Contra Indication
Inflammatory bowel disease, severe congestive heart failure, active peptic ulceration, cerebrovascular disease, CrCL <30 ml/min; lactation. Children and adolescent < 16 yr.
FDA has not yet classified the drug into a specified pregnancy category.
Mode of Action
Etoricoxib is a selective cyclooxygenase-2 (COX-2) inhibitor primarily responsible to reduce mediators of pain and inflammation. Its action is due to inhibition of prostaglandin synthesis via inhibition of COX-2.
Interaction
May increase INR w/ oral anticoagulants. May decrease effects of ACE inhibitors, angiotensin II antagonist and diuretics. May increase lithium plasma concentrations. May reduce plasma levels w/ rifampicin. Increased serum concentrations of ethinylestradiol.
Pregnancy Category Note
N/A
Adult Dose
Oral
Osteoarthritis
Adult: 30 mg once daily, increased to 60 mg once daily if needed.
Ankylosing spondylitis; Rheumatoid arthritis
Adult: 90 mg once daily.
Acute gout
Adult: 120 mg once daily. Max duration: 8 days.
Hepatic impairment: Mild (Child-Pugh score of 5-6): 60 mg once daily.
Moderate (Child-Pugh 7-9): Max 60 mg every other day or 30 mg once daily.
Severe (Child-Pugh >10): Avoid.
Child Dose
Child: <16 yr Contraindicated.
Renal Dose
N/A
Administration
May be taken with or without food.
Disclaimer
The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.