Chronic renal impairment; CHF; oedema; cirrhosis and low Na diets; patients with recent GI haemorrhage. Administer 2-3 hrs before/after another medication to minimise drug interactions. Pregnancy and lactation.
Lactation: excretion in milk unknown; use caution
>10%
Aluminum oxide,Chalky taste,Constipation,Fecal impaction,Stomach cramps
Frequency Not Defined
Aluminum oxide,Nausea,Vomiting,Aluminum intoxication,Hypophosphatemia,Osteomalacia,Magnesium oxide,Diarrhea,Hypermagnesemia
Pregnancy Category
Name :
C
Description
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks
Mode of Action
Alumunium hydroxide acts on the HCl in the stomach by neutralization, forming aluminium chloride salt and water.
Magnesium hydroxide increases peristaltic activity causing osmotic retention of fluids, thus resulting in bowel evacuation. It also reduces stomach acid by reacting with hydrochloric acid to form Mg chloride.
Interaction
Aluminium Hydroxide: Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.
Magnesium Hydroxide: Decreases absorption of tetracyclines and biphosphonates. Separate administration of these and other drugs by around 2 hr.
Pregnancy Category Note
Pregnancy Category: C
Lactation: excretion in milk unknown; use caution
Adult Dose
Adult: PO Gastric Hyperacidity, Heartburn: Up to 1 g/day.
Hyperphosphataemia in chronic renal failure Up to 10 g/day in divided doses w/ meals.
10-20 mL PO between meals & qHS
Child Dose
N/A
Renal Dose
N/A
Administration
May be taken with or without food.
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