Cosmotrin - 10gm

Cream

Pack Size : 1 Tube x 1 Packet

Generics : Tretinoin

Manufacturer : Beximco Pharmaceuticals Ltd.

Best Price * TK 45.00

* Delivery will be done in Dhaka city only.

Alternative Product

More Information About - Cosmotrin - 10gm

Description

Generic Name

Tretinoin Topical

Precaution

Avoid concomitant topical applications, esp keratolytic agents. Avoid exposure to sunlight, UV light and weather extremes (e.g. cold). Keep away from eyes, mouth, angles of nose, mucous membranes or open wounds. In case of severe local erythema, oedema, blistering or crusting, use less frequently or discontinue. Avoid medicated or drying soaps, abrasive soaps and cleansers, frequent washing and harsh scrubbing. Avoid use of topical preparations with high concentrations of alcohol, menthol, spices or lime.

Indication

Acne, Mottled hyperpigmentation, Roughness and fine wrinkling of photodamaged skin

Contra Indication

Hypersensitivity to retinoids. Application to eczematous, sunburnt or abraded skin. Pregnancy, lactation.

Dose

N/A

Side Effect

Initial exacerbation of symptoms, skin irritation, stinging on application, oedema, blistering, crusting of the skin, erythema, scaling, photosensitivity, temporary hypo/hyperpigmentation.

Pregnancy Category

Name : C

Description

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Mode of Action

Tretinoin is a trans-retinoic acid form of vitimin A. It stimulates mitosis and turnover of follicular epithelial cells and reduce their cohesiveness. This facilitates extrusion of existing comedones and prevents formation of new comedone. It also exhibits thinning effect on the stratum corneum. In acute promyelocytic leukaemia, it induces cellular differentiation and decreases proliferations.

Interaction

Enhances percutaneous absorption of minoxidil. Increased risk of fatal thrombotic complications with antifibrinolytic. Increased tretinoin concentrations with azole antifungals. Enhances peeling action of sulphur, resorcinol, benzoyl peroxide, salicylic acid. Increased photosensitivity with photosensitising medications eg, thiazides, tetracyclines, fluoroquinolones, phenothiazines and sulfonamides. Potentially Fatal: Increased risk of intracranial pressure with tetracyclines.

Pregnancy Category Note

Pregnancy category: C Lactation: Not known whether excreted in breast milk

Adult Dose

Topical/Cutaneous Acne vulgaris Adult: Apply once, usually at bedtime, onto affected area which has been previously cleansed to remove excessive oiliness and dried. Therapeutic response may be seen after 6-8 wk. Mottled hyperpigmentation, roughness and fine wrinkling of photodamaged skin Adult: Apply a pea-sized amount onto entire face once daily at night. Therapeutic response may be seen after 6 mth.

Child Dose

Topical/Cutaneous Acne Vulgaris <12 years: Safety and efficacy not established >12 years: Apply once, usually at bedtime, onto affected area

Renal Dose

N/A

Administration

N/A

Disclaimer

The information provided herein are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please note that this information should not be treated as a replacement for physical medical consultation or advice. Great effort has been placed to provide accurate and comprehensive data. However, Medicart along with its authors and editors make no representations or warranties and specifically disclaim all liability for any medical information provided on the site. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company.