Anaphylaxis and hypersensitivity have been reported with systemic use of azithromycin . Growth of resistant organisms may occur with prolonged use. patients should not wear contact lenses if they have signs or symptoms of bacterial conjunctivitis.
Lactation: Excretion in milk unknown; use with caution
Known hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic. Coadministration w/ pimozide. History of cholestatic jaundice/hepatic dysfunction associated w/ prior use of azithromycin.
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
Mode of Action
Azithromycin is a semisynthetic azalide antibiotic. It blocks transpeptidation by binding to 50s ribosomal subunit of susceptible organisms and disrupting RNA-dependent protein synthesis at the chain elongation step.
Interaction
N/A
Pregnancy Category Note
Pregnancy Category: B
Lactation: Excretion in milk unknown; use with caution
Adult Dose
Bacterial conjunctivitis
Adult: Instill 1 drop in the affected eye(s) bid for 2 days, then once daily for the next 5 days.
Child Dose
Bacterial conjunctivitis
Child >1 year: Instill 1 drop in the affected eye(s) bid for 2 days, then once daily for the next 5 days.
Renal Dose
N/A
Administration
N/A
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